PUBLICACIONES MÁS RECIENTES DE ESTOS PROYECTOS

TRABAJOS ORIGINALES

1. Paparini D, Grasso E, Calo G, Vota D, Hauk V, Ramhorst R, Pérez Leirós C. (2015) Trophoblast cells primed with vasoactive intestinal peptide enhance monocyte migration and apoptotic cell clearance through avß3 integrin portal formation in a model of maternal-placental interaction. Mol Hum Reprod. 2015 Dec;21(12):930-41. doi: 10.1093/molehr/gav059. Epub 2015 Oct 26. Pubmed
2. Fraccaroli L, Grasso E, Hauk V, Paparini D, Soczewski E, Mor G, Pérez Leirós C, Ramhorst R. (2015) VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction. J Leukoc Biol. 2015 Jul;98(1):49-58. doi: 10.1189/jlb.1A1014-492RR. Epub 2015 Apr 15. Pubmed
3. Paparini D, Gori S, Grasso E, Scordo W, Calo G, Pérez Leirós C, Ramhorst R, Salamone G. (2015) Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period. Acta Physiol (Oxf). 2015 Jun;214(2):237-47. doi: 10.1111/apha.12494. Epub 2015 Apr 6. Pubmed
4. Sóñora C, Calo G, Fraccaroli L, Pérez-Leirós C, Hernández A, Ramhorst R. (2014) Tissue transglutaminase on trophoblast cells as a possible target of autoantibodies contributing to pregnancy complications in celiac patients.Am J Reprod Immunol. 2014 Nov;72(5):485-95. doi: 10.1111/aji.12290. Epub 2014 Jul 24. Pubmed
5. Grasso E, Paparini D, Hauk V, Salamone G, Leiros CP, Ramhorst R.(2014) Differential migration and activation profile of monocytes after trophoblast interaction. PLoS One. 2014 May 21;9(5):e97147. doi: 10.1371/journal.pone.0097147. eCollection 2014. Pubmed
6. Hauk V, Fraccaroli L, Grasso E, Eimon A, Ramhorst R, Hubscher O, Pérez Leirós C. (2014) Monocytes from Sjögren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis. Clin Exp Immunol. 2014 Sep;177(3):662-70. doi: 10.1111/cei.12378. Pubmed
7. Grasso E, Paparini D, Agüero M, Mor G, Pérez Leirós C, Ramhorst R. (2014) VIP contribution to the decidualization program: regulatory T cell recruitment. J Endocrinol. 2014 Mar 13;221(1):121-31. doi: 10.1530/JOE-13-0565. Print 2014 Apr.Pubmed
8. Hauk V, Azzam S, Calo G, Gallino L, Paparini D, Franchi A, Ramhorst R, Leirós CP. (2014) Vasoactive intestinal Peptide induces an immunosuppressant microenvironment in the maternal-fetal interface of non-obese diabetic mice and improves early pregnancy outcome. Am J Reprod Immunol. Feb;71(2):120-30. doi: 10.1111/aji.12167. Epub 2013 Oct 28. Pubmed
9. Sóñora C, Mourglia-Ettlin G, Calo G, Hauk V, Ramhorst R, Hernández A, Leirós CP. (2013) Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice. J Reprod Immunol. pii: S0165-0378(13)00139-3. doi: 10.1016/j.jri.2013.11.001. [Epub ahead of print] Pubmed
10. Fraccaroli L, Grasso E, Hauk V, Cortelezzi M, Pérez Leirós C, Ramhorst R. (2014) Contribution of vasoactive intestinal peptide to immune homeostasis in trophoblast-maternal leukocyte interaction under LPS stimulation. Neuroimmunomodulation. 2014;21(1):21-30. doi: 10.1159/000355039. Epub 2013 Oct 12. Pubmed
11. Fraccaroli, Laura; Grasso, Esteban; Hauk, Vanesa; Cortelezzi, Marta; Calo, Guillermina; Pérez Leirós, Claudia; Ramhorst, Rosanna (2012). Defects in the VIP/VPAC system during early stages of the placental-maternal leukocyte interaction impair the maternal tolerogenic response. Clin Exp Immunol 170:310-320. Pubmed
12. Salamone G, Fraccaroli L, Gori S, Grasso E, Paparini D, Geffner J, Pérez Leirós C, Ramhorst R (2012). Trophoblast cells induce a tolerogenic profile in dendritic cells. Human Reproduction 27:2598-2606. Pubmed
13. Ramhorst R, Fraccaroli L, Aldo P, Alvero A, Cardenas I, Pérez Leirós C, Mor G (2012). Induction and recruitment of inducible regulatory T cells in an in vitro model of placental-maternal dialogue. Am J Reprod Immunol 67:17-27. Pubmed
14. Hauk V, Calafat M, Larocca L, Fraccaroli L, Grasso E, Ramhorst R, Pérez Leirós C (2011). VIP/VPAC relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sjögren's syndrome. Clin Exp Immunol 166:309-316. Pubmed
15. Larocca L*, Hauk V*, Calafat M, Roca V, Fraccaroli L, Franchi A, Ramhorst R, Pérez Leirós C (2011). Modulation of macrophage inflammatory profile in pregnant non obese diabetic (NOD) mice. Mol Cell Endocrinol 333: 112-118.*contribución idéntica. Pubmed
16. Fraccaroli L, Grasso E, Zeitler E, Lombardi E, Gogorza S, Etchepareborda JJ, Nagle C, Cortelezzi M, Perez Leirós C, Ramhorst R. (2010). Modulation of maternal LIF producers T cells by trophoblast and paternal antigens. Am J Reprod Immunol. 65:133-145. Pubmed
17. Roca V, Calafat M, Larocca L, Ramhorst R, Farina M, Franchi AM, Perez Leiros C (2009). Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice. Reproduction 138:733-742. Pubmed
18. Fraccaroli L, Alfieri J, Leiros CP, Ramhorst R (2009). Immunomodulatory effects of chemokines during the early implantation window. Front Biosci (Elite Ed). 1:288-298. Pubmed
19. Calafat M, Larocca L, Roca V, Hauk V, Pregi N, Nesse, A, Perez Leiros C (2009). Vasoactive intestinal peptide inhibits TNF-?-induced apoptotic events in acinar cells from nonobese diabetic mice (NOD) submandibular glands. Arthritis Res Ther 11:R53. Pubmed
20. Fraccaroli L, Alfieri J, Larocca L, Calafat M, Roca V, Lombardi E, Ramhorst R, Pérez Leirós C (2009). VIP modulates the pro-inflammatory maternal response inducing tolerance to trophoblast-cells. Br J Pharmacol 156:116-126. Pubmed
21. Pregi N, Wenker S, Vittori D, Perez Leirós C, Nesse A(2009).TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells. Exp Cell Res 315:419-431. Pubmed
22. Fraccaroli L, Alfieri J, Larocca L, Calafat M, Mor Gil, Pérez Leirós C, Ramhorst R. (2009) A potential tolerogenic immune mechanism by trophoblast cells through the activation of chemokine-induced T cell death and regulatory T cell modulation. Human Reproduction 24:166-175. Pubmed
23. Calafat M, Larocca L, Roca V, Pérez Leirós C (2007). NOD mice exocrinopathy: towards a neuroimmune link. Neuroimmunomodulation. 14:175-181. Pubmed
24. Larocca L., Calafat M, Roca V, Franchi, A, Pérez Leirós C (2007). VIP limits LPS-induced nitric oxide production through IL-10 in NOD mice macrophages. Int. Immunopharmacol. 7:1343-1349. Pubmed

REVISIONES, EDITORIALES Y OTROS ARTÍCULOS

1. Hauk V, Calafat M, Paparini D, Ramhorst R, Pérez Leirós C. (2014). Role of VIP/VPAC system in immune homeostasis maintenance: A neuroimmune approach to Sjögren's Syndrome pathogenesis. Curr Pharm Design 20(29):4760-5.
2. Pérez Leirós C, Ramhorst R. (2013) Tolerance induction at the early maternal-placental interface through selective cell recruitment and targeting by immune polypeptides. Am J Reprod Immunol. 2013 Apr;69(4):359-68. doi: 10.1111/aji.12087. Epub 2013 Feb 14. Pubmed
3. Grasso E, Fraccaroli L, Hauk V, Gallino L, Calo G, Pérez Leirós C, Ramhorst R. (2012) ¿El reconocimiento alogénico debe bloquearse para lograr un embarazo exitoso? Revista de Soc Arg Endocrinología y Ginecología Reproductiva (SAEGRE) (en prensa). REVISION
4. Pérez Leirós C, Arzt E, Saravia F, Rettori V. (2010). Preface. Iberoamerican Congress on Neuroimmunomodulation. Neuroimmunomodulation 17(3):137-138. EDITORIAL Pubmed
5. Larocca L, Ramhorst R, Roca V, Calafat M, Aisemberg J, Franchi A, Pérez Leirós C (2008). Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: focus on macrophage activation. Neuroimmunomodulation 15:84-90. REVISION Pubmed
6. Larocca L, Calafat M, Roca V, Ramhorst R y Pérez Leirós C. (2008) El lenguaje químico de la interacción inmune-neuroendócrina. Revista Química Viva 7(3). REVISION Link a revista
7. Fraccaroli L, Alfieri J, Larocca L, Roca R, Lombardi E, Pérez Leirós C, Ramhorst R. (2008). VIP: Un neuropéptido capaz de modular la respuesta inflamatoria implantatoria y la alorespuesta materna. Una mirada inmune-neuroendocrina de la implantación fetal. Revista de SAEGRE 15(2): 67-75. ARTICULO ORIGINAL (Premio Mendizábal de Ginecología). Link a artículo

CAPITULOS DE LIBROS

Hauk V, Calafat M, Fraccaroli L, Grasso E, Ramhorst R, Pérez Leirós C. El sistema VIP/VPAC en el mantenimiento de la homeostasis inmunológica: Un abordaje neuroinmune a la patogenia del Síndrome de Sjögren. En Neuroinmunomodulación: Interacciones inmunoneuroendócrinas en salud y enfermedad. Editorial Fiocruz, Rio de Janeiro, Brasil, Eds. Savino W, Bauer M. et al. En prensa 2012

Grasso E, Fraccaroli L, Hauk V, Pérez Leirós C, Ramhorst R. Participación de inmunomoduladores en etapas tempranas de la gestación. En Avances en Endocrinología Ginecológica y Reproductiva. (2012). Eds. De la Parra, Cortelezzi, Kopelman, Lombardi. Sociedad Argentina de Endocrinología Ginecológica y Reproductiva. Editorial Ascune. Buenos Aires.

Ramhorst R, Roca V, Larocca L, Fraccaroli L, Alfieri J, Pérez Leirós C. An immunopharm-acological view on the maternal-fetal early interaction under physiological and pathological conditions. En Inflammatory mediators of normal and pathologic pregnancy. (2011) Ed. Res Signpost. Eds: Pandalai SG, Ribeiro ML & Farina M. ISBN: 978-81-308-0397-7

NOTAS DE DIVULGACIÓN

1. Opinión: Un nuevo enfoque del 'diálogo' materno-fetal: Los beneficios del reconocimiento de aloantígenos. Grasso E, Baudou F, Fraccaroli L, Hauk V, Paparini D, Pérez Leirós C, Ramhorst R. QuímicaViva (2011) Vol 10 Num 1.

2. Opinión: La aspirina y los caminos diversos del desarrollo de nuevos fármacos, Pérez Leirós C. QuímicaViva (2010) 9(2) http://www.quimicaviva.qb.fcen.uba.ar/v9n2/perezleiros.html

3. Opinión: Medicamentos para el estilo de vida (y para el debate). Pérez Leirós C. Química Viva (2005) 4(2).http://www.quimicaviva.qb.fcen.uba.ar/V4n2/Medicamentos.html